Reassortment with Dominant Chicken H9N2 Influenza Virus Contributed to the Fifth H7N9 Virus Human Epidemic-Reference-Cited by-同舟云学术

Reassortment with Dominant Chicken H9N2 Influenza Virus Contributed to the Fifth H7N9 Virus Human Epidemic

Published:2021-05-10 Issue:11 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Pu Juan¹,Yin Yanbo²,Liu Jiyu¹^ORCID,Wang Xinyu¹,Zhou Yong¹,Wang Zejiang¹,Sun Yipeng¹,Sun Honglei¹^ORCID,Li Fangtao¹,Song Jingwei¹,Qu Runkang¹,Gao Weihua¹,Wang Dongdong²,Wang Zhen¹,Yan Shijie¹,Chen Mingyue¹,Zeng Jinfeng³,Jiang Zhimin¹,Sun Haoran¹,Zong Yanan¹,Wang Chenxi¹,Tong Qi¹,Bi Yuhai⁴,Huang Yinhua⁵,Du Xiangjun³^ORCID,Chang Kin-Chow⁶,Liu Jinhua¹^ORCID

Affiliation:

1. Key Laboratory of Animal Epidemiology, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China

2. College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China

3. School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, China

4. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China

5. State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China

6. School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, United Kingdom

Abstract

Avian H9N2 influenza virus, although primarily restricted to chicken populations, is a major threat to human public health by acting as a donor of variant viral genes through reassortment to cocirculating influenza viruses. We established that the high prevalence of evolving H9N2 virus in vaccinated flocks played a key role as a donor of new subclade PB2 and PA genes in the generation of a dominant H7N9 virus genotype (genotype 72 [G72]) with enhanced infectivity in humans during the 2016–2017 N7N9 virus epidemic.

Funder

Project of Poultry Industry Innovation Team of Shandong Provincial Modern Agricultural Industry Technology System

National Key Research and Development Program

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01578-20

Reference49 articles.

1. Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus