T-Cell Immunophenotyping and Cytokine Production Analysis in Patients with Chagas Disease 4 Years after Benznidazole Treatment-Reference-Cited by-同舟云学术

T-Cell Immunophenotyping and Cytokine Production Analysis in Patients with Chagas Disease 4 Years after Benznidazole Treatment

Published:2019-08 Issue:8 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Llaguno Mauricio¹²,da Silva Marcos Vinicius¹^ORCID,Batista Lara Rocha¹,da Silva Djalma Alexandre Alves¹,de Sousa Rodrigo Cunha³,de Resende Luiz Antonio Pertili Rodrigues³,da Silva Valdo Jose Dias⁴,Lages-Silva Eliane¹,Oliveira Carlo José Freire¹,Machado Juliana Reis⁵,Rodrigues Denise Bertulucci Rocha⁶⁷,Correia Dalmo³,Rodrigues Virmondes¹

Affiliation:

1. Department of Microbiology, Immunology and Parasitology, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil

2. Faculty of Medicine, University of Franca (UNIFRAN), Franca, São Paulo, Brazil

3. Department of Internal Medicine, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil

4. Department of Biochemistry, Pharmacology and Physiology, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil

5. Department of Pathology, Genetics and Evolution, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil

6. CEFORES, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil

7. Laboratory of Biopathology and Molecular Biology, University of Uberaba (UNIUBE), Uberaba, Minas Gerais, Brazil

Abstract

The major problem with Chagas disease is evolution of the chronic indeterminate form to a progressive cardiac disease. Treatment diminishes parasitemia but not clinical progression, and the immunological features involved are unclear. Here, we studied the clinical course and the immune response in patients with chronic-phase Chagas disease at 48 months after benznidazole treatment.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00103-19

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