Relative Contributions of Active Mediated Transport and Passive Diffusion of Fluoroquinolones with Various Lipophilicities in a Calu-3 Lung Epithelial Cell Model-Reference-Cited by-同舟云学术

Relative Contributions of Active Mediated Transport and Passive Diffusion of Fluoroquinolones with Various Lipophilicities in a Calu-3 Lung Epithelial Cell Model

Published:2010-01 Issue:1 Volume:54 Page:543-545
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Brillault Julien¹²,De Castro Whocely Victor¹²,Couet William¹²³

Affiliation:

1. INSERM, ERI-23, 40 avenue du Recteur Pineau, Poitiers, France

2. Université de Poitiers, UFR Médecine-Pharmacie, 6 rue de la Milétrie, Poitiers, France

3. CHU Poitiers, 2 rue de la Milétrie, Poitiers, France

Abstract

ABSTRACT The transport characteristics of six fluoroquinolones (FQs) with various lipophilicities were compared in a Calu-3 cell model. For each FQ, an active polarized transport was observed in the direction of the apical side. However, the apparent permeability of FQs resulted from active transport and passive diffusion that were highly variable between compounds and mainly governed by lipophilicity. Therefore, active transport was predominant for compounds with relatively low lipophilicity but minor for FQs with higher lipophilicity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00733-09

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