Growth and Drug Resistance Phenotypes Resulting from Cytomegalovirus DNA Polymerase Region III Mutations Observed in Clinical Specimens-Reference-Cited by-同舟云学术

Growth and Drug Resistance Phenotypes Resulting from Cytomegalovirus DNA Polymerase Region III Mutations Observed in Clinical Specimens

Published:2007-11 Issue:11 Volume:51 Page:4160-4162
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chou Sunwen¹²,Marousek Gail I.²,Van Wechel Laura C.¹,Li Shaobing³,Weinberg Adriana³⁴

Affiliation:

1. Division of Infectious Diseases, Oregon Health and Science University

2. VA Medical Center, Portland, Oregon

3. Divisions of Infectious Diseases

4. Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado

Abstract

ABSTRACT Recombinant phenotyping of cytomegalovirus (CMV) pol region III mutations from clinical specimens showed that T813S and G841A each conferred foscarnet resistance and approximately threefold increased ganciclovir resistance; adding the UL97 mutation C592G increased ganciclovir resistance to approximately sixfold. Bacterial artificial chromosome CMV clones containing pol mutation L845P were nonviable unless repaired with the wild-type sequence.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00736-07

Reference14 articles.

1. Cloning of the Human Cytomegalovirus (HCMV) Genome as an Infectious Bacterial Artificial Chromosome in Escherichia coli : a New Approach for Construction of HCMV Mutants

2. Chou, S., G. Marousek, S. Guentzel, S. E. Follansbee, M. E. Poscher, J. P. Lalezari, R. C. Miner, and W. L. Drew. 1997. Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease. J. Infect. Dis.176:786-789.

3. Chou, S., G. Marousek, D. M. Parenti, S. M. Gordon, A. G. LaVoy, J. G. Ross, R. C. Miner, and W. L. Drew. 1998. Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy. J. Infect. Dis.178:526-530.

4. Phenotyping of Cytomegalovirus Drug Resistance Mutations by Using Recombinant Viruses Incorporating a Reporter Gene

5. Chou, S., L. C. van Wechel, and G. I. Marousek. 2007. Cytomegalovirus UL97 kinase mutations that confer maribavir resistance. J. Infect. Dis.196:91-94.

Cited by 59 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Detecting drug-resistant human cytomegalovirus mutations in liver transplant recipients: A study of the UL97 gene;Gene Reports;2024-09

2. Cytomegalovirus, a “Friend” of SARS-CoV-2: A Case Report;Children;2024-08-19

3. Management of Cytomegalovirus Infections in the Era of the Novel Antiviral Players, Letermovir and Maribavir;Infectious Disease Reports;2024-01-18

4. Resistance to antiviral drugs in human viruses from the subfamily <i>Betaherpesvirinae</i>;Problems of Virology;2022-11-19

5. Infections in lung transplanted patients: A review;Pulmonology;2022-06