Abstract
In endemic areas where Salmonella and Schistosoma species co-occur, several lines of evidence suggest a synergistic bacteria-parasite interaction that results in a protracted course for the salmonella infection that has proven difficult to diagnose and therapeutically remedy. In an in vitro system using a pilus-negative and a pilus-producing transductant strain of Salmonella typhimurium we show that pili are the ligands for bacterial adherence to the schistosome surface tegument. Antipili antibodies produced in rabbits against purified pili, purified and digested to monovalent (Fab) fragments, blocked the association of Salmonella sp. to the surface tegument of Schistosoma sp., further demonstrating that pili are the appendages necessary for bacteria-parasite surface interaction. The use of carbohydrates, lectins, and enzymes demonstrated that the bacteria-parasite surface interaction was specific, mediated by pili that specifically recognize and bind to mannose-like receptors, probably glycolipids, on the surface of the worms. We suggest that prolonged salmonellosis in schistosome-infected patients is due to an association of Salmonella sp. with the schistosome worms themselves and further that the schistosome worms provide a multiplication focus for these bacteria in the portal mesenteric system, with a persisting bacteremia following.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference49 articles.
1. a-Galactosidase, ,Bgalactosidase, f-glucosidase, p-N-acetyl glucosaminidase, and a-mannosidase from pinto beans (Phaseolus vulgaris);Agrawal K. M. L.;Methods Enzymol.,1972
2. Effects of experimental Salmonella dublin infection in cattle given Fasciola hepatica thirteen weeks previously;Aitken M. M.;J. Comp. Pathol.,1978
3. Infection of schistosomes with gram-positive cocci;Basch P. F.;Nature (London),1971
4. Nematospiroides dubius as a vector for Salmonella typhimurium;Bottjer K. P.;Am. J. Vet. Res.,1978
5. Etudes in vivo et in vitro des relations entre Schistosoma mansoni et certaines souches D'enterobacteries;Bouillard C.;Bull. Soc. Pathol. Exot.,1982
Cited by
54 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献