Variations in the Abilities of Several Lines of L Cells to Produce and to Be Affected by Interferon

Author:

Lockart Royce Z.1

Affiliation:

1. Department of Microbiology, The University of Texas, Austin, Texas

Abstract

Lockart, Royce Z., Jr . (The University of Texas, Austin). Variations in the abilities of several lines of L cells to produce and to be affected by interferon. J. Bacteriol. 89: 117–122. 1965.—The amounts of interferon produced by three different lines of L cells and mouse embryonic cells when inoculated with two strains of Western equine encephalomyelitis (WEE) virus and Newcastle disease virus (NDV) were determined. One cell line consistently produced more interferon than the others. NDV stimulated more interferon than did WEE virus in all the cell lines tested. The interferons failed to show homologous specificity in their ability to inhibit virus production in the three cell lines. The cell line that produced the most interferon also was most sensitive to viral inhibition. This cell line was also most sensitive to the viral inhibitory ability of an interferon prepared in mouse embryonic cells.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference17 articles.

Cited by 14 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. A MICRO ASSAY FOR MOUSE AND HUMAN INTERFERON.;Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology;2009-08-15

2. Interferon assay;Journal of Immunological Methods;1981-10

3. Interferon production by mammalian cells grown in a serum-free medium;In Vitro;1979-05

4. Cellular interactions determine the rate and degree of interferon action;Infection and Immunity;1979-02

5. T-antigen expression in human skin fibroblasts is not regulated by an endogenous interferon response to SV40 infection;Archives of Virology;1978-12

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