Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases-Reference-Cited by-同舟云学术

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases

Published:2022-03-09 Issue:5 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chaudhry M. Zeeshan¹^ORCID,Eschke Kathrin¹,Hoffmann Markus²³,Grashoff Martina⁴,Abassi Leila¹,Kim Yeonsu¹,Brunotte Linda⁵,Ludwig Stephan⁵^ORCID,Kröger Andrea⁴⁶,Klawonn Frank⁷⁸,Pöhlmann Stefan H.²³^ORCID,Cicin-Sain Luka¹⁹^ORCID

Affiliation:

1. Department of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

2. Infection Biology Unit, German Primate Center, Göttingen, Germany

3. Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany

4. Research Group Innate Immunity and Infection, Helmholtz Centre for Infection Research, Braunschweig, Germany

5. Institut für Virologie (IMV), Westfälische Wilhelms-Universität Münster, Münster, Germany

6. Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University, Magdeburg, Germany

7. Biostatistics Group, Helmholtz Centre for Infection Research, Braunschweig, Germany

8. Department of Computer Science, Ostfalia University, Wolfenbüttel, Germany

9. Centre for Individualized Infection Medicine (CIIM), Hannover, Germany

Abstract

Recently emerging SARS-CoV-2 variants B.1.1.7 (alpha variant), B.1.617.2 (delta variant), and B.1.1.529 (omicron variant) harbor spike mutations and have been linked to increased virus pathogenesis. The emergence of these novel variants highlights coronavirus adaptation and evolution potential, despite the stable consensus genotype of clinical isolates.

Funder

Helmholtz Association

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.02186-21

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