Evaluation of Serological SARS-CoV-2 Lateral Flow Assays for Rapid Point-of-Care Testing

Author:

Conklin Steven E.1,Martin Kathryn1,Manabe Yukari C.2,Schmidt Haley A.1,Miller Jernelle1,Keruly Morgan3,Klock Ethan2,Kirby Charles S.1,Baker Owen R.3,Fernandez Reinaldo E.2,Eby Yolanda J.1,Hardick Justin2,Shaw-Saliba Kathryn4,Rothman Richard E.4,Caturegli Patrizio P.1,Redd Andrew D.23,Tobian Aaron A. R.12,Bloch Evan M.1,Larman H. Benjamin1,Quinn Thomas C.23,Clarke William1,Laeyendecker Oliver23ORCID

Affiliation:

1. Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

2. Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

3. Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

4. Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Abstract

Rapid point-of-care tests (POCTs) for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies vary in performance. A critical need exists to perform head-to-head comparisons of these assays.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference34 articles.

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3. Immunoassays

4. Lateral flow assays

5. Joseph A Branswell H. 24 April 2020. The results of coronavirus ‘serosurveys’ are starting to be released. Here’s how to kick their tires. Stat. https://www.statnews.com/2020/04/24/the-results-of-coronavirus-serosurveys-are-starting-to-be-released-heres-how-to-kick-their-tires/.

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