Phylogenetic Analysis of Mycobacterium tuberculosis Strains in Wales by Use of Core Genome Multilocus Sequence Typing To Analyze Whole-Genome Sequencing Data-Reference-Cited by-同舟云学术

Phylogenetic Analysis of Mycobacterium tuberculosis Strains in Wales by Use of Core Genome Multilocus Sequence Typing To Analyze Whole-Genome Sequencing Data

Published:2019-06 Issue:6 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Jones R. C.¹,Harris L. G.¹,Morgan S.²,Ruddy M. C.³,Perry M.³,Williams R.³,Humphrey T.¹,Temple M.²,Davies A. P.¹⁴

Affiliation:

1. Swansea University Medical School, Institute of Life Science, Swansea University, Swansea, Wales, United Kingdom

2. Health Protection Division (Mid and West Wales), Public Health Wales, Swansea, Wales, United Kingdom

3. Wales Centre for Mycobacteriology, Llandough Hospital, Cardiff, Wales, United Kingdom

4. Public Health Wales Microbiology, Swansea, Wales, United Kingdom

Abstract

An inability to standardize the bioinformatic data produced by whole-genome sequencing (WGS) has been a barrier to its widespread use in tuberculosis phylogenetics. The aim of this study was to carry out a phylogenetic analysis of tuberculosis in Wales, United Kingdom, using Ridom SeqSphere software for core genome multilocus sequence typing (cgMLST) analysis of whole-genome sequencing data.

Funder

Coleg Cymraeg Cenedlaethol

St. David's Medical Foundation

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02025-18

Reference31 articles.

1. Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans

2. Variable host-pathogen compatibility in Mycobacterium tuberculosis