Cryptococcus neoformans Isolates from Transplant Recipients Are Not Selected for Resistance to Calcineurin Inhibitors by Current Immunosuppressive Regimens-Reference-Cited by-同舟云学术

Cryptococcus neoformans Isolates from Transplant Recipients Are Not Selected for Resistance to Calcineurin Inhibitors by Current Immunosuppressive Regimens

Published:2005-01 Issue:1 Volume:43 Page:464-467
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Blankenship Jill R.¹,Singh Nina²,Alexander Barbara D.³,Heitman Joseph¹³⁴

Affiliation:

1. Departments of Molecular Genetics and Microbiology

2. Division of Infectious Diseases, Pittsburgh Veterans Affairs Medical Center, Pittsburgh, Pennsylvania

3. Medicine

4. Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina

Abstract

ABSTRACT The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious course but does not appear to be the consequence of immunosuppressive therapy.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.43.1.464-467.2005

Reference37 articles.

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