Accumulation of Clostridium perfringens Epsilon-Toxin in the Mouse Kidney and Its Possible Biological Significance-Reference-Cited by-同舟云学术

Accumulation of Clostridium perfringens Epsilon-Toxin in the Mouse Kidney and Its Possible Biological Significance

Published:2003-09 Issue:9 Volume:71 Page:5371-5375
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Tamai Eiji¹,Ishida Tetsuya²,Miyata Shigeru¹,Matsushita Osamu¹,Suda Hirofumi³,Kobayashi Shoji⁴,Sonobe Hiroshi⁵,Okabe Akinobu¹

Affiliation:

1. Department of Microbiology

2. Department of Anatomy

3. Radioisotope Research Center

4. Department of Diagnostic Pathology, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Kita-gun, Kagawa 761-0793

5. Department of Laboratory Medicine and Pathology, National Fukuyama Hospital, Fukuyama City 720-8520, Japan

Abstract

ABSTRACT In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the lethal toxicity of epsilon-toxin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.9.5371-5375.2003

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