Dynamics and Determinants of Staphylococcus aureus Carriage in Infancy: the Generation R Study

Author:

Lebon Ankie123,Labout Joost A. M.12,Verbrugh Henri A.3,Jaddoe Vincent W. V.124,Hofman Albert14,van Wamel Willem3,Moll Henriette A.12,van Belkum Alex3

Affiliation:

1. The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands

2. Department of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands

3. Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands

4. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Abstract

ABSTRACT Serial nasal swabs were collected at the ages of 1.5, 6, and 14 months from 443 infants in the Generation R Study. The objective was to study the dynamics and determinants of Staphylococcus aureus nasal carriage in the first year of life. The prevalence of S. aureus carriage decreased in the first year of life, from 52.1% at the age of 1.5 months to 12.9% at 14 months. Persistent carriage, defined as continuous carriage of the same S. aureus strain at the three sampling moments, was rarely detected in early infancy.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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