Plasmodium falciparum and TNF-α Differentially Regulate Inflammatory and Barrier Integrity Pathways in Human Brain Endothelial Cells-Reference-Cited by-同舟云学术

Plasmodium falciparum and TNF-α Differentially Regulate Inflammatory and Barrier Integrity Pathways in Human Brain Endothelial Cells

Published:2022-10-26 Issue:5 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zuniga Marisol¹,Gomes Claudia¹,Chen Ze¹,Martinez Criseyda²,Devlin Joseph Cooper¹,Loke P’ng³^ORCID,Rodriguez Ana¹^ORCID

Affiliation:

1. Department of Microbiology, New York University School of Medicine, New York, New York, USA

2. Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA

3. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

Abstract

Cerebral malaria is a severe complication of Plasmodium falciparum infection that causes the loss of blood-brain barrier integrity and frequently results in death. Here, we compared the effect of P. falciparum -infected red blood cells and inflammatory cytokines, like TNF-α, in the loss of BBB integrity.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Neurological Disorders and Stroke

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01746-22

Reference77 articles.

1. WHO. 2021. World malaria report 2021. https://www.who.int/publications/i/item/9789240040496.