RanDeL-Seq: a High-Throughput Method to Map Viral cis - and trans -Acting Elements-Reference-Cited by-同舟云学术

RanDeL-Seq: a High-Throughput Method to Map Viral cis - and trans -Acting Elements

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Notton Timothy¹²,Glazier Joshua J.¹,Saykally Victoria R.¹,Thompson Cassandra E.¹,Weinberger Leor S.¹³^ORCID

Affiliation:

1. Gladstone Center for Cell Circuitry, Gladstone Institutes, San Francisco, California, USA

2. University of California, Berkeley, San Francisco Joint Graduate Group in Bioengineering, San Francisco, California, USA

3. Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA

Abstract

Recent studies have renewed interest in developing novel antiviral therapeutics and vaccines based on defective interfering particles (DIPs)—a subset of viral deletion mutants that conditionally replicate. Identifying and engineering DIPs require that viral cis - and trans -acting elements be accurately mapped.

Funder

DOD | Defense Advanced Research Projects Agency

HHS | NIH | OSC | Common Fund

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01724-20

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