Membrane Protein OTOF Is a Type I Interferon-Induced Entry Inhibitor of HIV-1 in Macrophages-Reference-Cited by-同舟云学术

Membrane Protein OTOF Is a Type I Interferon-Induced Entry Inhibitor of HIV-1 in Macrophages

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Ding Haibo¹²,Zhang Xiaowei¹²,Zhu Zheming¹,Wang Shumei¹,Xiong Ying¹²,Shang Hong¹²³,Liang Guoxin¹⁴²^ORCID

Affiliation:

1. Key Laboratory of AIDS Immunology of Ministry of Health, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China

2. National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China

3. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China

4. Research Institute for Cancer Therapy, The First Affiliated Hospital, China Medical University, Shenyang, China

Abstract

In patients with HIV-1 infection, the virus is recognized by innate immune sensors that trigger the production of type I interferons (IFNs), which are well-known cytokines that exert broad antiviral effects by inducing the expression of antiviral genes. By comparing the gene expression profiles of untreated patients and healthy donors, we systematically identified OTOF as a new antiviral gene induced by IFN-α in primary macrophages and dendritic cells (DCs).

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01738-22

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