Systematic Analysis of Copy Number Variations in the Pathogenic Yeast Candida parapsilosis Identifies a Gene Amplification in <i>RTA3</i> That is Associated with Drug Resistance-Reference-Cited by-同舟云学术

Systematic Analysis of Copy Number Variations in the Pathogenic Yeast Candida parapsilosis Identifies a Gene Amplification in RTA3 That is Associated with Drug Resistance

Published:2022-10-26 Issue:5 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Bergin Sean A.¹,Zhao Fang¹,Ryan Adam P.¹,Müller Carolin A.²,Nieduszynski Conrad A.³⁴,Zhai Bing⁵⁶⁷,Rolling Thierry⁵⁶,Hohl Tobias M.⁵⁶⁸^ORCID,Morio Florent⁹,Scully Jillian¹,Wolfe Kenneth H.¹⁰^ORCID,Butler Geraldine¹^ORCID

Affiliation:

1. School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland

2. Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

3. Earlham Institute, Norwich, United Kingdom

4. School of Biological Sciences, University of East Anglia, Norwich, United Kingdom

5. Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

6. Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA

7. Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

8. Department of Medicine, Weill Cornell Medical College, New York, New York, USA

9. Nantes Université, CHU de Nantes, Cibles et Médicaments des Infections et de l'Immunité, IICiMed, Nantes, France

10. School of Medicine, Conway Institute, University College Dublin, Belfield, Dublin, Ireland

Abstract

Copy number variations (CNVs) are an important source of genomic diversity that have been associated with drug resistance. We identify two unusual CNVs in the human fungal pathogen Candida parapsilosis .

Funder

Science Foundation Ireland

Irish Research Council

Deutsche Forschungsgemeinschaft

HHS | National Institutes of Health

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01777-22