<i>N</i> -Succinyltransferase Encoded by a Cryptic Siderophore Biosynthesis Gene Cluster in <i>Streptomyces</i> Modifies Structurally Distinct Antibiotics-Reference-Cited by-同舟云学术

N -Succinyltransferase Encoded by a Cryptic Siderophore Biosynthesis Gene Cluster in Streptomyces Modifies Structurally Distinct Antibiotics

Published:2022-10-26 Issue:5 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Schneider Olha¹,Zehl Martin²,Ueoka Reiko³,Rückert Christian⁴^ORCID,Buche Tobias⁴,Jiang Yi⁵^ORCID,Li Qin-Yuan⁵⁶,Piel Jörn³,Zotchev Sergey B.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Vienna, Austria

2. Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria

3. Department of Biology, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland

4. Center for Biotechnology, Bielefeld University, Bielefeld, Germany

5. Yunnan Institute of Microbiology, Yunnan University, Kunming, People’s Republic of China

6. Life Sciences Lab Center, School of Life Sciences, Yunnan University, Kunming, People’s Republic of China

Abstract

In their natural habitats, bacteria encounter a plethora of organic compounds, some of which may be represented by antibiotics produced by certain members of the microbial community. A number of antibiotic resistance mechanisms have been described, including those specified by distinct genes encoding proteins that degrade, modify, or expel antibiotics.

Funder

Universität Wien

Eidgenössische Technische Hochschule Zürich

Yunnan University

Austrian Science Fund

Universität Bielefeld

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01789-22