Viral Suppression of RIPK1-Mediated Signaling-Reference-Cited by-同舟云学术

Viral Suppression of RIPK1-Mediated Signaling

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Udawatte Darshika J.¹²,Rothman Alan L.¹²^ORCID

Affiliation:

1. Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island, USA

2. Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island, USA

Abstract

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has emerged as a key upstream regulator of cell death and inflammation. RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1), Toll-like receptor 3 (TLR3), TLR4, retinoic acid-inducible gene 1 (RIG-I)/melanoma differentiation-associated protein 5 (MDA-5), and Z-binding protein 1 (ZBP1) by signaling for NF-κB activation, mitogen-associated protein kinase (MAPK) and IRF3/7 phosphorylation, and cell death via apoptosis and necroptosis.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01723-21

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