Affiliation:
1. Department of Molecular Biosciences and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
Abstract
Shigella
is an intracellular pathogen that invades the human host cell cytosol and exploits intracellular nutrients for growth, enabling the bacterium to create its own metabolic niche. For
Shigella
to effectively invade and replicate within the host cytoplasm, it must sense and adapt to changing environmental conditions; however, the mechanisms and signals sensed by
S. flexneri
are largely unknown. We have found that the secreted
Shigella
metabolism by-product formate regulates
Shigella
intracellular virulence gene expression and its ability to spread among epithelial cells. We propose that
Shigella
senses formate accumulation in the host cytosol as a way to determine intracellular
Shigella
density and regulate secreted virulence factors accordingly, enabling spatiotemporal regulation of effectors important for dampening the host immune response.
Funder
HHS | NIH | National Institute of Allergy and Infectious Diseases
Publisher
American Society for Microbiology
Cited by
30 articles.
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