Antifungal Triazole Posaconazole Targets an Early Stage of the Parechovirus A3 Life Cycle-Reference-Cited by-同舟云学术

Antifungal Triazole Posaconazole Targets an Early Stage of the Parechovirus A3 Life Cycle

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rhoden Eric¹,Ng Terry Fei Fan¹^ORCID,Campagnoli Ray¹,Nix W. Allan¹,Konopka-Anstadt Jennifer¹,Selvarangan Rangaraj²,Briesach Laurence³,Oberste M. Steven¹,Weldon William C.¹

Affiliation:

1. Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Children’s Mercy Hospital, Kansas City, Missouri, USA

3. IHRC, Inc., Atlanta, Georgia, USA

Abstract

Viruses in species Parechovirus A ( Picornaviridae ) are associated with a wide variety of clinical manifestations. Parechovirus A3 (PeV-A3) is known to cause sepsis-like illness, meningitis, and encephalitis in infants and young children. To date, no specific therapies are available to treat PeV-A3-infected children. We had previously identified two FDA-cleared antifungal drugs, itraconazole (ITC) and posaconazole (POS), with potent and specific antiviral activity against PeV-A3.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02372-19

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