Role of Plk2 ( Snk ) in Mouse Development and Cell Proliferation-Reference-Cited by-同舟云学术

Role of Plk2 ( Snk ) in Mouse Development and Cell Proliferation

Published:2003-10 Issue:19 Volume:23 Page:6936-6943
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Ma Sheng¹,Charron Jean²,Erikson Raymond L.¹

Affiliation:

1. Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138

2. Centre de Recherche en Cancérologie de l'Université Laval, L'Hôtel-Dieu de Québec, CHUQ, Québec, Canada G1R 2J6

Abstract

ABSTRACT Plk2 (Snk) is a polo-like kinase expressed at G 1 in cultured cells and mainly in the hippocampal neurons in the brains of adult rodents, but its function is poorly understood. We have generated mice deficient in Plk2 by gene targeting. Although Plk2 is not required for postnatal growth, Plk2 −/− embryos show retarded growth and skeletal development late in gestation. The labyrinthine zone of the placenta is diminished in Plk2 −/− embryos due to decreased cell proliferation. Cultured Plk2 −/− embryonic fibroblasts grow more slowly than normal cells and show delayed entry into S phase. These data suggest a role for Plk2 in the cell cycle.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.23.19.6936-6943.2003

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