Nonneutralizing Antibodies Are Able To Inhibit Human Immunodeficiency Virus Type 1 Replication in Macrophages and Immature Dendritic Cells-Reference-Cited by-同舟云学术

Nonneutralizing Antibodies Are Able To Inhibit Human Immunodeficiency Virus Type 1 Replication in Macrophages and Immature Dendritic Cells

Published:2006-06-15 Issue:12 Volume:80 Page:6177-6181
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Holl Vincent¹,Peressin Maryse¹,Decoville Thomas¹,Schmidt Sylvie¹,Zolla-Pazner Susan²,Aubertin Anne-Marie¹,Moog Christiane¹

Affiliation:

1. EA 3770, ULP, Institut de Virologie, 3 rue Kœberlé, 67000 Strasbourg, France

2. Veterans Affairs and NYU Medical Centers, 423 East 23rd Street, Room 18124N, New York, New York 10010

Abstract

ABSTRACT Only five monoclonal antibodies (MAbs) neutralizing a broad range of primary isolates (PI) have been identified up to now. We have found that some MAbs with no neutralizing activities according to the “conventional” neutralization assay, involving phytohemagglutinin-stimulated peripheral blood mononuclear cells as targets, efficiently inhibit the replication of human immunodeficiency virus type 1 (HIV-1) PI in macrophages and immature dendritic cells (iDC). The mechanism of inhibition is distinct from the neutralization of infectivity occurring via Fab fragments and involves the interaction of the F portion with the FcγRs present on macrophages and iDC. We propose that, if such nonneutralizing inhibitory antibodies limit mucosal HIV transmission, they should be induced by vaccination.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02625-05

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