ICAM-1 Participates in the Entry of West Nile Virus into the Central Nervous System-Reference-Cited by-同舟云学术

ICAM-1 Participates in the Entry of West Nile Virus into the Central Nervous System

Published:2008-04-15 Issue:8 Volume:82 Page:4164-4168
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Dai Jianfeng¹,Wang Penghua¹,Bai Fengwei¹,Town Terrence²³,Fikrig Erol¹

Affiliation:

1. Section of Infectious Diseases, Department of Internal Medicine

2. Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520

3. Department of Biomedical Sciences and Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048

Abstract

ABSTRACT Determining how West Nile virus crosses the blood-brain barrier is critical to understanding the pathogenesis of encephalitis. Here, we show that ICAM-1 −/− mice are more resistant than control animals to lethal West Nile encephalitis. ICAM-1 −/− mice have a lower viral load, reduced leukocyte infiltration, and diminished neuronal damage in the brain compared to control animals. This is associated with decreased blood-brain barrier leakage after viral infection. These data suggest that ICAM-1 plays an important role in West Nile virus neuroinvasion and that targeting ICAM-1 signaling may help control viral encephalitis.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02621-07

Reference33 articles.

1. Anderson, M. E., and T. J. Siahaan. 2003. Targeting ICAM-1/LFA-1 interaction for controlling autoimmune diseases: designing peptide and small molecule inhibitors. Peptides24:487-501.

2. Bella, J., and M. G. Rossmann. 2000. ICAM-1 receptors and cold viruses. Pharm. Acta Helv.74:291-297.

3. Bolton, S. J., D. C. Anthony, and V. H. Perry. 1998. Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo. Neuroscience86:1245-1257.

4. Chancey, C. J., K. V. Khanna, J. F. Seegers, G. W. Zhang, J. Hildreth, A. Langan, and R. B. Markham. 2006. Lactobacilli-expressed single-chain variable fragment (scFv) specific for intercellular adhesion molecule 1 (ICAM-1) blocks cell-associated HIV-1 transmission across a cervical epithelial monolayer. J. Immunol.176:5627-5636.

5. T-cell-mediated immunity to lymphocytic choriomeningitis virus in beta2-integrin (CD18)- and ICAM-1 (CD54)-deficient mice

Cited by 71 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus 1 CNS infection;2024-08-19

2. Orchestration of antiviral responses within the infected central nervous system;Cellular & Molecular Immunology;2024-07-12

3. Pathophysiology of chikungunya virus infection associated with fatal outcomes;Cell Host & Microbe;2024-04

4. Proteome Analysis for Inflammation Related to Acute and Convalescent Infection;Inflammation;2023-10-13

5. Mechanisms of Neuroinvasion and Neuropathogenesis by Pathologic Flaviviruses;Viruses;2023-01-17