Pregenomic RNA Is Required for Efficient Incorporation of Pol Polyprotein into Foamy Virus Capsids-Reference-Cited by-同舟云学术

Pregenomic RNA Is Required for Efficient Incorporation of Pol Polyprotein into Foamy Virus Capsids

Published:2002-10 Issue:19 Volume:76 Page:10069-10073
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Heinkelein Martin¹²,Leurs Cordula³,Rammling Matthias²,Peters Katrin¹²,Hanenberg Helmut³,Rethwilm Axel¹²

Affiliation:

1. Institut für Virologie, Medizinische Fakultät “Carl Gustav Carus,” Technische Universität Dresden, Dresden

2. Institut für Virologie und Immunbiologie, Universität Würzburg, Würzburg

3. Kinderklinik, Universität Düsseldorf, Düsseldorf, Germany

Abstract

ABSTRACT The foamy virus (FV) Pol polyprotein is translated independently of Gag from a spliced mRNA. This method of expression raises the question of how Pol is associated with the viral particle. Using a transient FV vector transfection system, it is shown that pregenomic RNA is required for efficient virion incorporation of functionally active Pol and that protein-protein interactions of Pol with Gag are not sufficient to complete particle assembly.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.19.10069-10073.2002

Reference23 articles.

1. The Roles of Pol and Env in the Assembly Pathway of Human Foamy Virus

2. Proteolytic Activity, the Carboxy Terminus of Gag, and the Primer Binding Site Are Not Required for Pol Incorporation into Foamy Virus Particles

3. Association of Murine Leukemia Virus Pol with Virions, Independent of Gag-Pol Expression

4. Carboxy-terminal cleavage of the human foamy virus Gag precursor molecule is an essential step in the viral life cycle

5. Enssle, J., I. Jordan, B. Mauer, and A. Rethwilm. 1996. Foamy virus reverse transcriptase is expressed independently from the gag protein. Proc. Natl. Acad. Sci. USA 93 : 4137-4141.

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