Targeting and Hematopoietic Suppression of Human CD34 + Cells by Measles Virus-Reference-Cited by-同舟云学术

Targeting and Hematopoietic Suppression of Human CD34 + Cells by Measles Virus

Published:2002-07 Issue:13 Volume:76 Page:6636-6642
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Manchester Marianne¹²,Smith Kent A.³,Eto Danelle S.¹²,Perkin Hugh B.³,Torbett Bruce E.³

Affiliation:

1. Departments of Cell Biology

2. Center for Integrative Molecular Biosciences, The Scripps Research Institute, La Jolla, California 92037

3. Molecular and Experimental Medicine

Abstract

ABSTRACT The major cause of mortality in measles is generalized suppression of cell-mediated immunity that persists following virus clearance and results in secondary infections. The mechanisms contributing to this long-term immunosuppression are not clear. Herein we present evidence that measles virus (MV) disrupts hematopoiesis by infecting human CD34 + cells and human bone marrow stroma. MV infection does not affect the hematopoietic capability of hematopoietic stem cells (HSCs) directly; rather, the infection impairs the ability of stroma to support development of HSCs. These results suggest that MV-mediated defects in hematopoiesis contribute to the long-term immunosuppression seen in measles.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.13.6636-6642.2002

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