Immune Responses to the Major Capsid Protein during Parvovirus Infection of Rats-Reference-Cited by-同舟云学术

Immune Responses to the Major Capsid Protein during Parvovirus Infection of Rats

Published:2002-10 Issue:19 Volume:76 Page:10044-10049
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ball-Goodrich Lisa J.¹,Paturzo Frank X.¹,Johnson Elizabeth A.¹,Steger Krista²,Jacoby Robert O.¹

Affiliation:

1. Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8016

2. Forge 4ward, Inc., Somerville, New Jersey 08876

Abstract

ABSTRACT Rat virus (RV) is a common parvovirus of laboratory rodents which can disrupt rat-based research. Prenatal or perinatal infection can be pathogenic or lead to persistent infection, whereas infection of adult rats is typically self-limiting. Effects on the host immune system have been documented during RV infection, but little is known about immune responses necessary for viral clearance. Our studies were conducted to identify humoral and cellular responses to the predominant capsid protein, VP2, during experimental infection of adult rats. We observed VP2-specific proliferation, gamma interferon production, and an immunoglobulin G2a humoral response that is maintained for at least 35 days following RV infection. These results strongly suggest the induction of virus-specific Th1-mediated immunity.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.19.10044-10049.2002

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