Park-Williams Number 8 Strain of Corynebacterium diphtheriae

Author:

Lampidis Theodore1,Barksdale Lane1

Affiliation:

1. New York University School of Medicine and Medical Center, New York, New York 10016

Abstract

Five clones of the Park-Williams number 8 strain of Corynebacterium diphtheriae , previously maintained in separate laboratories, were examined for their colonial and biochemical properties, for the restriction and modification system which operates to obscure their lysogeny, and for their capacity to produce large amounts of toxin under ordinary laboratory conditions. The phenotypes of their phage, P, produced in strain 603 and C7 (P·603 and P·C7) differ both as to stability to storage in the cold and to inactivation by antiphage serum. Evidence for a high degree of stability in the integration of P prophage in the PW8 genome is presented.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference40 articles.

1. Adams M. H. 1959. Bacteriophages. Interscience Publishers Inc. New York.

2. Arber W. 1965. Host-controlled restriction and modification of bacteriophage p. 295-314. In L. V. Crawford and M. G. P. Stoker (ed.). The molecular biology of viruses. Symp. Soc. Gen. Microbiol. 18th Cambridge.

3. Host specificity of DNA produced by Escherichia coli. 1. Host controlled modification of bacteriophage A;Arber W.;J. Mol. Biol.,1962

4. Sur quelques bacteriophages de Corrnebacterium diphtheriae et leur hotes;Barksdale L.;C. R. H. Acad. Sci.,1955

5. Virulence, toxigeny and Iysogeny in Corynebacterium diphtheriae;Barksdale L.;Ann. N. Y. Acad. Sci.,1960

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