Monoclonal Antibodies Targeting Surface-Exposed Epitopes of Candida albicans Cell Wall Proteins Confer <i>In Vivo</i> Protection in an Infection Model-Reference-Cited by-同舟云学术

Monoclonal Antibodies Targeting Surface-Exposed Epitopes of Candida albicans Cell Wall Proteins Confer In Vivo Protection in an Infection Model

Published:2022-04-19 Issue:4 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Palliyil Soumya¹^ORCID,Mawer Mark¹²,Alawfi Sami A.²,Fogg Lily¹,Tan Tyng H.¹²,De Cesare Giuseppe Buda²,Walker Louise A.²^ORCID,MacCallum Donna M.²,Porter Andrew J.¹,Munro Carol A.²

Affiliation:

1. Scottish Biologics Facility, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom

2. Aberdeen Fungal Group, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom

Abstract

Monoclonal antibody (mAb)-based immunotherapies targeting systemic and deep-seated fungal infections are still in their early stages of development, with no licensed antifungal mAbs currently being available for patients at risk. The cell wall glycoproteins of Candida albicans are of particular interest as potential targets for therapeutic antibody generation due to their extracellular location and key involvement in fungal pathogenesis.

Funder

University of Aberdeen

Taibah University and Saudi Government Scholarship

Horizon 2020 Research and Innovation Program

ABDN | College of Life Sciences and Medicine, University of Aberdeen

UKRI | Medical Research Council

SULSA High Throughput and Fragment Screening Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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