Uncoating Kinetics of Hepatitis A Virus Virions and Provirions

Author:

Bishop Naomi E.1,Anderson David A.1

Affiliation:

1. Hepatitis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria, Australia 3078

Abstract

ABSTRACT When the growth kinetics of immature hepatitis A virus provirions and mature virions were monitored, distinct eclipse phases were noted for both types of particles. Strikingly, uncoating of virions occurred around 4 h postinfection, while uncoating of provirions occurred predominantly between 8 and 10 h postinfection. It is proposed that the heterogenous mixture of infectious hepatitis A virus particles (virions and provirions) typically present in inocula is responsible for the normally asynchronous nature of hepatitis A virus uncoating kinetics.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference32 articles.

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