Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon-Reference-Cited by-同舟云学术

Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon

Published:2000-04 Issue:7 Volume:74 Page:3404-3409
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Deonarain Raj¹,Alcamí Antonio²,Alexiou Maria¹,Dallman Margaret J.³,Gewert Dirk R.⁴,Porter Andrew C. G.¹

Affiliation:

1. MRC Clinical Science Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN,1

2. Division of Virology, Department of Pathology, Cambridge University, Cambridge CB2 1QP,2

3. Department of Biology, Imperial College of Science Technology and Medicine, South Kensington, London SW7 2AZ,3 and

4. QT Genetics Ltd., Cambridge CB4 3GA,4 United Kingdom

Abstract

ABSTRACT We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.7.3404-3409.2000

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