Role of Gamma Interferon in Controlling Murine Chlamydial Genital Tract Infection

Author:

Ito James I.1,Lyons Joseph M.1

Affiliation:

1. Department of Infectious Diseases, City of Hope National Medical Center, Duarte, California 91010

Abstract

ABSTRACT Earlier investigations have not shown an important role for gamma interferon (IFN-γ) in the early clearance of chlamydial infection from the murine female genital tract. In a model using a human genital isolate of Chlamydia trachomatis in IFN-γ and IFN-γ receptor knockout mice, we were able to demonstrate a major role for IFN-γ in mediating control of infection throughout the course of infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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