Antisense Inhibition of Expression of Cysteine Proteinases Affects Entamoeba histolytica -Induced Formation of Liver Abscess in Hamsters-Reference-Cited by-同舟云学术

Antisense Inhibition of Expression of Cysteine Proteinases Affects Entamoeba histolytica -Induced Formation of Liver Abscess in Hamsters

Published:1999-01 Issue:1 Volume:67 Page:421-422
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ankri Serge¹,Stolarsky Tamara¹,Bracha Rivka¹,Padilla-Vaca Felipe¹,Mirelman David¹

Affiliation:

1. Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel

Abstract

ABSTRACT Trophozoites of virulent Entamoeba histolytica transfected with the antisense gene encoding cysteine proteinase 5 (CP5) have only 10% of the CP activity but retain their cytopathic activity on mammalian monolayers. In the present study we found that the transfected trophozoites with low levels of CP activity were incapable of inducing the formation of liver lesions in hamsters.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.67.1.421-422.1999

Reference19 articles.

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