Nonrestricted Differential Intoxication of Cells by Pertussis Toxin

Author:

el Bayâ Ali1,Brückener Kerstin1,Schmidt M. Alexander1

Affiliation:

1. Institut für Infektiologie - Zentrum für Molekularbiologie der Entzündung, Westfälische Wilhelms-Universität Münster, D-48149 Münster, Germany

Abstract

ABSTRACT After uptake and retrograde transport pertussis toxin acts by ADP-ribosylating α-G i proteins. We show that uptake via many different receptor proteins followed by retrograde transport and intoxication is not restricted to a particular cell type. The efficiency of cellular intoxication, however, was found to be cell type dependent.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference8 articles.

1. Lectin-like binding of pertussis toxin to a 165-kilodalton Chinese hamster ovary cell glycoprotein;Brennan M. J.;J. Biol. Chem.,1988

2. Identification of binding proteins for pertussis toxin on pancreatic β cell-derived insulin-secreting cells;El Bayâ A.;Microb. Pathog.,1995

3. Endocytosis and retrograde transport of pertussis toxin to the Golgi complex as a prerequisite for cellular intoxication;El Bayâ A.;Eur. J. Cell Biol.,1997

4. Entry of cholera toxin into polarized human intestinal epithelial cells;Lencer W. I.;J. Clin. Investig.,1993

5. Brefeldin A blocks the response of cultured cells to cholera toxin;Orlandi P. A.;J. Biol. Chem.,1993

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