Consolidating and Exploring Antibiotic Resistance Gene Data Resources

Author:

Xavier Basil Britto1,Das Anupam J.1,Cochrane Guy2,De Ganck Sandra1,Kumar-Singh Samir13,Aarestrup Frank Møller4,Goossens Herman1,Malhotra-Kumar Surbhi1

Affiliation:

1. Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, Universiteit Antwerpen, Antwerp, Belgium

2. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, United Kingdom

3. Laboratory of Molecular Pathology, Cell Biology and Histology, Faculty of Medicine and Health Sciences, Universiteit Antwerpen, Antwerp, Belgium

4. National Food Institute, Technical University of Denmark, Lyngby, Denmark

Abstract

ABSTRACT The unrestricted use of antibiotics has resulted in rapid acquisition of antibiotic resistance (AR) and spread of multidrug-resistant (MDR) bacterial pathogens. With the advent of next-generation sequencing technologies and their application in understanding MDR pathogen dynamics, it has become imperative to unify AR gene data resources for easy accessibility for researchers. However, due to the absence of a centralized platform for AR gene resources, availability, consistency, and accuracy of information vary considerably across different databases. In this article, we explore existing AR gene data resources in order to make them more visible to the clinical microbiology community, to identify their limitations, and to propose potential solutions.

Funder

EU Horizon 2020

University of Antwerp research funds BOF DOCPRO

Research Foundation Flanders

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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