A human monoclonal antibody which inhibits the coaggregation activity of Porphyromonas gingivalis-Reference-Cited by-同舟云学术

A human monoclonal antibody which inhibits the coaggregation activity of Porphyromonas gingivalis

Published:1997-09 Issue:9 Volume:65 Page:3966-3969
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Abiko Y¹,Ogura N¹,Matsuda U¹,Yanagi K¹,Takiguchi H¹

Affiliation:

1. Department of Biochemistry, Nihon University School of Dentistry at Matsudo, Chiba, Japan. yabiko@mascat.nihon-u.ac.jp

Abstract

A B-cell line producing a human monoclonal antibody (HuMAb) against a recombinant 40-kDa outer membrane protein (OMP) of Porphyromonas gingivalis was constructed by in vivo immunization of a severe combined immunodeficiency C.B.-17/Icr mouse, which had been injected with human peripheral blood lymphocytes, with recombinant 40-kDa OMP and subsequent Epstein-Barr virus immortalization of B cells isolated from the spleen of the mouse. This HuMAb inhibited coaggregation between P. gingivalis vesicles and Actinomyces naeslundii cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.65.9.3966-3969.1997

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