Macrophage Depletion Reactivates Fecal Virus Shedding following Resolution of Acute Hepatitis A in<i>Ifnar1</i><sup>–/

Macrophage Depletion Reactivates Fecal Virus Shedding following Resolution of Acute Hepatitis A inIfnar1^–/–Mice

Published:2022-12-14 Issue:23 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Shiota Tomoyuki¹²,Matsuda Mami¹,Zheng Xin¹,Nagata Noriyo³,Ishii Koji¹,Suzuki Ryosuke¹^ORCID,Muramatsu Masamichi¹^ORCID,Takimoto Kazuhiro⁴,Hanaki Ken-Ichi⁴,Lemon Stanley M.²⁵⁶^ORCID,McGivern David R.²⁵^ORCID,Hirai-Yuki Asuka⁴^ORCID

Affiliation:

1. Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

2. Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

3. Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan

4. Management Department of Biosafety, Laboratory Animal and Pathogen Bank, National Institute of Infectious Diseases, Tokyo, Japan

5. Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

6. Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Abstract

HAV RNA persists in the liver of infected chimpanzees and interferon receptor-deficientIfnar1−/−mice for many months after neutralizing antibodies appear, virus has been cleared from the blood, and fecal virus shedding has terminated. Here, we show this viral RNA is located within hepatocytes and that the depletion of macrophages months after the resolution of hepatic inflammation restores fecal virus shedding and circulating viral RNA.

Funder

HHS | National Institutes of Health

Japan Agency for Medical Research and Development

US-Japan Co-operative Medical Science Program Collaborative Award

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01496-22

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