Susceptibilities of Human ACE2 Genetic Variants in Coronavirus Infection

Author:

Ren Wenlin1,Zhu Yunkai2,Lan Jun3,Chen Hedi4,Wang Yuyan2,Shi Hongyang5,Feng Fei2,Chen Da-Yuan67,Close Brianna67,Zhao Xiaomin1,Wu Jianping8,Tian Boxue4,Yuan Zhenghong2,Zhou Dongming9,Saeed Mohsan67ORCID,Wang Xinquan3,Zhang Rong2,Ding Qiang1ORCID

Affiliation:

1. Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China

2. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

3. School of Life Sciences, Tsinghua University, Beijing, China

4. School of Pharmaceutical Sciences, Tsinghua University, Beijing, China

5. CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

6. Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA

7. National Emerging Infectious Diseases Laboratories, Boston University, Boston, Massachusetts, USA

8. Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China

9. Department of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

Abstract

There is considerable variation in disease severity among patients infected with SARS-CoV-2, the virus that causes COVID-19. Human genetic variation can affect disease outcome, and the coronaviruses SARS-CoV, SARS-CoV-2, and HCoV-NL63 utilize human ACE2 as the receptor to enter cells.

Funder

Tsinghua University

Beijing Municipal Natural Science Foundation

Start-Up Foundation of Tsinghua University

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Cited by 27 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3