Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa

Published:2020-03-24 Issue:4 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gudiol C.¹²³^ORCID,Albasanz-Puig A.¹³,Laporte-Amargós J.¹,Pallarès N.⁴,Mussetti A.⁵,Ruiz-Camps I.⁶³,Puerta-Alcalde P.⁷³,Abdala E.⁸,Oltolini C.⁹,Akova M.¹⁰,Montejo M.¹¹³,Mikulska M.¹²,Martín-Dávila P.¹³³,Herrera F.¹⁴,Gasch O.¹⁵³,Drgona L.¹⁶,Paz Morales H.¹⁷,Brunel A.-S.¹⁸,García E.¹⁹,Isler B.²⁰,Kern W. V.²¹,Morales I.²²³,Maestro-de la Calle G.²³,Montero M.²⁴³,Kanj S. S.²⁵,Sipahi O. R.²⁶,Calik S.²⁷,Márquez-Gómez I.²⁸,Marin J. I.²⁹³⁰,Gomes M. Z. R.³¹^ORCID,Hemmatti P.³²,Araos R.³³³⁴,Peghin M.³⁵,del Pozo J. L.³⁶,Yáñez L.³⁷,Tilley R.³⁸,Manzur A.³⁹,Novo A.⁴⁰,Carratalà J.¹³,

Affiliation:

1. Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Barcelona, Spain

2. Institut Català d’Oncologia (ICO)-Hospital Duran i Reynals, IDIBELL, Barcelona, Spain

3. Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0001), Instituto de Salud Carlos III, Madrid, Spain

4. Statistics Advisory Service, Institute of Biomedical Research of Bellvitge, Barcelona, Spain

5. Haematology Department, Institut Català d’Oncologia (ICO)-Hospital Duran i Reynals, IDIBELL, Barcelona, Spain

6. Infectious Diseases Department, Vall d’Hebron University Hospital, Barcelona, Spain

7. Infectious Diseases Department, Hospital Clínic i Provincial, Barcelona, Spain

8. Instituto do Câncer do Estado de São Paulo, Faculty of Medicine, University of São Paulo, São Paulo, Brazil

9. Unit of Infectious and Tropical Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy

10. Department of Infectious Diseases, Hacettepe University School of Medicine, Ankara, Turkey

11. Infectious Diseases Unit, Cruces University Hospital, Bilbao, Spain

12. Division of Infectious Diseases, University of Genoa (DISSAL) and Ospedale Policlinico San Martino, Genoa, Italy

13. Infectious Diseases Department, Ramon y Cajal Hospital, Madrid, Spain

14. Infectious Diseases Section, Department of Medicine, Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina

15. Infectious Diseases Department, Parc Taulí University Hospital, Sabadell, Spain

16. Oncohematology Department, Comenius University and National Cancer Institute, Bratislava, Slovakia

17. Infectious Diseases Department, Hospital Erasto Gaertner, Curitiba, Brazil

18. Infectious Diseases Department, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland

19. Haematology Department, Reina Sofía University Hospital-IMIBIC-UCO, Córdoba, Spain

20. Department of Infectious Diseases and Clinical Microbiology, Istanbul Education and Research Hospital, Istanbul, Turkey

21. Division of Infectious Diseases, Department of Medicine II, University of Freiburg Medical Center and Faculty of Medicine, Freiburg, Germany

22. Emergency Clinical Unit and Infectious Diseases Division, Hospital Universitario Virgen Macarena, Seville, Spain

23. Infectious Diseases Unit, Instituto de Investigación Hospital 12 de Octubre (i+12), 12 de Octubre University Hospital, School of Medicine, Universidad Complutense, Madrid, Spain

24. Infectious Diseases Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’Investigations Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, Barcelona, Spain

25. Infectious Diseases Division, American University of Beirut Medical Center, Beirut, Lebanon

26. Ege University Faculty of Medicine, Izmir, Turkey

27. University of Health Science Izmir Bozyaka Training and Research Hospital, Izmir, Turkey

28. Infectious Diseases Department, Hospital Regional de Málaga, Málaga, Spain

29. Infectious Diseases and Clinical Microbiology Department, Clínica Maraya, Pereira, Colombia

30. Critical Care and Clinical Microbiology Department, Manizales, Colombia

31. Hospital Federal dos Servidores do Estado and Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Ministério da Saúde, Rio de Janeiro, Brazil

32. Department of Hematology, Oncology and Palliative Care, Klinikum Ernst von Bergmann, Academic Teaching Hospital of Charité University Medical School, Berlin, Germany

33. Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago de Chile, Chile

34. Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago de Chile, Chile

35. Infectious Diseases Clinic, Department of Medicine, University of Udine and Azienda Sanitaria Universitaria Integrata, Udine, Italy

36. Infectious Diseases and Microbiology Unit, Navarra University Clinic, Pamplona, Spain

37. Haematology Department, Marqués de Valdecilla University Hospital, Santander, Spain

38. Microbiology Department, University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom

39. Infectious Diseases, Hospital Rawson, San Juan, Argentina

40. Haematology Department, Son Espases University Hospital, Palma de Mallorca, Spain

Abstract

We aimed to assess the rate and predictive factors of bloodstream infection (BSI) due to multidrug-resistant (MDR) Pseudomonas aeruginosa in neutropenic cancer patients. We performed a multicenter, retrospective cohort study including oncohematological neutropenic patients with BSI due to P. aeruginosa conducted across 34 centers in 12 countries from January 2006 to May 2018. A mixed logistic regression model was used to estimate a model to predict the multidrug resistance of the causative pathogens.

Funder

Spanish Network for Research in Infectious Diseases (REIPI

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02494-19

Reference37 articles.

1. Changing aetiology, clinical features, antimicrobial resistance, and outcomes of bloodstream infection in neutropenic cancer patients

2. Bloodstream infections in neutropenic cancer patients: A practical update

3. Aetiology and resistance in bacteraemias among adult and paediatric haematology and cancer patients