Antifungal Susceptibility and Mutations in the Squalene Epoxidase Gene in Dermatophytes of the Trichophyton mentagrophytes Species Complex-Reference-Cited by-同舟云学术

Antifungal Susceptibility and Mutations in the Squalene Epoxidase Gene in Dermatophytes of the Trichophyton mentagrophytes Species Complex

Published:2021-07-16 Issue:8 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kong Xue¹²^ORCID,Tang Chao²,Singh Ashutosh³,Ahmed Sarah A.²,Al-Hatmi Abdullah M. S.²⁴,Chowdhary Anuradha³^ORCID,Nenoff Pietro⁵,Gräser Yvonne⁶,Hainsworth Steven⁷,Zhan Ping⁸,Meis Jacques F.²⁹^ORCID,Verweij Paul E.²^ORCID,Liu Weida¹¹⁰¹¹^ORCID,de Hoog G. Sybren¹²

Affiliation:

1. Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, China

2. Center of Expertise in Mycology Radboud University Medical Center/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

3. Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India

4. Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, Oman

5. Laboratory for Medical Microbiology, Mölbis, Germany

6. Universitätsmedizin Berlin-Charité, Institut für Mikrobiologie und Hygiene, Nationales Konsiliarlabor für Dermatophyten, Berlin, Germany

7. School of Science, RMIT University (Bundoora Campus), Bundoora, Australia

8. Dermatology Hospital of Jiangxi Provinces, Jiangxi Dermatology Institute, Nanchang, China

9. Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands

10. Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China

11. Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, Jiangsu, China

Abstract

During the past decade, a prolonged and serious outbreak of dermatophytosis due to a terbinafine-resistant novel species in the Trichophyton mentagrophytes - T. interdigitale complex has been ongoing in India, and it has spread to several European countries. The objective of this study was to investigate the molecular background of the squalene epoxidase ( SQLE ) gene in order to understand the risk of emergence and spread of multiresistance in dermatophytes.

Funder

Scientific and Technological Innovation Projects of Medicine and Health of Chinese Academy of Medical Sciences

Nanjing Incubation Program for National Clinical Research Center

Basical Scientific Research Fund Projects of Chinese Academy of Medical Sciences

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00056-21

Reference37 articles.

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4. Perspectives on misidentification of Trichophyton interdigitale /Trichophyton mentagrophytes using internal transcribed spacer region sequencing: Urgent need to update the sequence database

5. A unique multidrug-resistant clonal Trichophyton population distinct from Trichophyton mentagrophytes/Trichophyton interdigitale complex causing an ongoing alarming dermatophytosis outbreak in India: Genomic insights and resistance profile

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