Affiliation:
1. Infectious Diseases Service, St. Jude Children's Research Hospital, and Departments of Pediatrics and Microbiology, University of Tennessee Medical Units, Memphis, Tennessee 38101
Abstract
A combination of trimethoprim and sulfamethoxazole was effective in the prevention and treatment of
Pneumocystis carinii
pneumonitis in cortisonetreated rats. Although all of 15 untreated rats died with
P. carinii
pneumonitis, none of 15 given trimethoprim-sulfamethoxazole prophylactically acquired the infection. After
P. carinii
pneumonitis was established, 9 of 14 rats recovered after treatment with trimethoprim-sulfamethoxazole compared with only 2 of 14 treated with pentamidine isethionate. Rifampin and clindamycin, separately or in combination with pentamidine, were ineffective in the prevention and treatment of
P. carinii
infection.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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