Human Leukocyte Antigen Class II Alleles Influence Levels of Antibodies to the Plasmodium falciparum Asexual-Stage Apical Membrane Antigen 1 but Not to Merozoite Surface Antigen 2 and Merozoite Surface Protein 1-Reference-Cited by-同舟云学术

Human Leukocyte Antigen Class II Alleles Influence Levels of Antibodies to the Plasmodium falciparum Asexual-Stage Apical Membrane Antigen 1 but Not to Merozoite Surface Antigen 2 and Merozoite Surface Protein 1

Published:2004-05 Issue:5 Volume:72 Page:2762-2771
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Johnson Armead H.¹,Leke Rose G. F.²³,Mendell Nancy R.⁴,Shon Dewon⁴,Suh Young Ju⁵⁶,Bomba-Nkolo Dennis²,Tchinda Viviane³,Kouontchou Samuel³,Thuita Lucy W.⁷,van der Wel Anne Marie⁸,Thomas Alan⁸,Stowers Anthony⁹,Saul Allan⁹¹⁰,Zhou Ainong⁷,Taylor Diane W.⁷,Quakyi Isabella A.⁷

Affiliation:

1. Departments of Pediatrics

2. Faculty of Medicine and Biomedical Sciences

3. The Biotechnology Center, University of Yaounde I, Yaounde, Cameroon

4. Department of Applied Mathematics, State University of New York, Stony Brook, New York

5. Department of Statistics, Seoul National University

6. Clinical Research Institute, Seoul National University Hospital, Seoul, Korea

7. Biology, Georgetown University, Washington, D.C.

8. Biomedical Primate Research Centre, Rijswijk, The Netherlands

9. Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

10. The Queensland Institute of Medical Research and The University of Queensland, Brisbane, Australia

Abstract

ABSTRACT The apical membrane antigen 1 (AMA1), merozoite surface antigen 2 (MSA2), and merozoite surface protein 1 (MSP1) are asexual-stage proteins currently being evaluated for inclusion in a vaccine for Plasmodium falciparum . Accordingly, it is important to understand factors that control antibody responses to these antigens. Antibody levels in plasma from residents of Etoa, Cameroon, between the ages of 5 and 70 years, were determined using recombinant AMA1, MSA2, and the N-terminal region of MSP1 (MSP1-190L). In addition, antibody responses to four variants of the C-terminal region of MSP1 (MSP1 19 ) were assessed. Results showed that all individuals produced antibodies to AMA1, MSA2, and MSP1-190L; however, a proportion of individuals never produced antibodies to the MSP1 19 variants, although the percentage of nonresponders decreased with age. The influence of age and human leukocyte antigen (HLA)-DRB1/DQB1 alleles on antibody levels was evaluated using two-way analysis of variance. Age was correlated with levels of antibodies to AMA1 and MSP1 19 but not with levels of antibodies to MSA2 and MSP1-190L. No association was found between a single HLA allele and levels of antibodies to MSA2, MSP1-190L, or any of the MSP1 19 variants. However, individuals positive for DRB1*1201 had higher levels of antibodies to the variant of recombinant AMA1 tested than did individuals of all other HLA types. Since the effect was seen across all age groups, HLA influenced the level but not the rate of antibody acquisition. This association for AMA1, combined with the previously reported association between HLA class II alleles and levels of antibodies to rhoptry-associated protein 1 (RAP1) and RAP2, indicates that HLA influences the levels of antibodies to three of the five vaccine candidate antigens that we have evaluated.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.5.2762-2771.2004

Reference52 articles.

1. Al-Yaman, F., B. Genton, R. F. Anders, M. Falk, T. Triglia, D. Lewis, J. Hii, H.-P. Beck, and M. P. Alpers. 1994. Relationship between humoral response to Plasmodium falciparum merozoite surface antigen-2 and malaria morbidity in a highly endemic area of Papua New Guinea. Am. J. Trop. Med. Hyg.51:593-602.

2. Al-Yaman, F., B. Genton, K. J. Krammer, S. P. Chang, G. S. Hui, M. Baisor, and M. P. Alpers. 1996. Assessment of the role of naturally acquired antibody levels to Plasmodium falciparum merozoite surface protein-1 in protecting Papua New Guinean children from malaria morbidity. Am. J. Trop. Med. Hyg.54:443-448.

3. Beck, H.-P., I. Felger, M. Barker, T. Bugawan, B. Genton, N. Alexander, E. Jazwinska, H. Erlich, and M. Alpers. 1995. Evidence of HLA class II association with antibody response against the malaria vaccine SPf66 in a naturally exposed population. Am. J. Trop. Med. Hyg.53:284-288.

4. Blackman, J. J., H.-G. Heidrich, S. Donachie, J. S. McBride, and A. A. Holder. 1990. A single fragment of a malaria merozoite surface protein remains on the parasite surface during red cell invasion and is the target of invasion-inhibiting antibodies. J. Exp. Med.172:379-382.

5. Branch, O. H., V. Udhayakumar, A. W. Hightower, A. J. Oloo, W. A. Hawley, B. L. Nahlen, P. B. Bloland, D. C. Kaslow, and A. A. Lal. 1998. A longitudinal investigation of IgG and IgM antibody responses to the merozoite surface protein-1 19-kilodalton domain of Plasmodium falciparum in pregnant women and infants: associations with febrile illness, parasitemia, and anemia. Am. J. Trop. Med. Hyg.58:211-219.

Cited by 25 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antibody dynamics in children with first or repeat Plasmodium falciparum infections;Frontiers in Medicine;2022-07-19

2. Impacts of Ecology, Parasite Antigenic Variation, and Human Genetics on RTS,S/AS01e Malaria Vaccine Efficacy;Current Epidemiology Reports;2021-07-30

3. Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon;Infectious Diseases of Poverty;2018-05-14

4. Synthetic Antigens Derived from Plasmodium falciparum Sporozoite, Liver, and Blood Stages: Naturally Acquired Immune Response and Human Leukocyte Antigen Associations in Individuals Living in a Brazilian Endemic Area;The American Journal of Tropical Medicine and Hygiene;2017-11-08

5. Immunogenicity and protection from malaria infection in BK-SE36 vaccinated volunteers in Uganda is not influenced by HLA-DRB1 alleles;Parasitology International;2016-10