The Extra Cytoplasmic Function Sigma Factor σ E Is Essential for Mycobacterium tuberculosis Virulence in Mice-Reference-Cited by-同舟云学术

The Extra Cytoplasmic Function Sigma Factor σ E Is Essential for Mycobacterium tuberculosis Virulence in Mice

Published:2004-05 Issue:5 Volume:72 Page:3038-3041
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Manganelli Riccardo¹,Fattorini Lanfranco²,Tan Dejiang²,Iona Elisabetta²,Orefici Graziella²,Altavilla Giuseppe³,Cusatelli Paola³,Smith Issar⁴

Affiliation:

1. Department of Histology, Microbiology and Medical Biotechnologies

2. Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Rome, Italy

3. Institute of Pathologic Anatomy and Histology, University of Padua, Padua

4. TB Center, Public Health Research Institute, International Center for Public Health, Newark, New Jersey

Abstract

ABSTRACT The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.5.3038-3041.2004

Reference14 articles.

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