Dynein Light-Chain Dynlrb2 Is Essential for Murine Leukemia Virus Traffic and Nuclear Entry-Reference-Cited by-同舟云学术

Dynein Light-Chain Dynlrb2 Is Essential for Murine Leukemia Virus Traffic and Nuclear Entry

Published:2021-07-12 Issue:15 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Pietrantoni Gianfranco¹,Gaete-Argel Aracelly²³,Herrera-Rojo Diego¹,Ibarra-Karmy Rodrigo¹,Bustos Fernando J.¹,Valiente-Echeverría Fernando²³^ORCID,Arriagada Gloria¹⁴^ORCID

Affiliation:

1. Instituto de Ciencias Biomédicas, Facultad de Medicina y Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile

2. Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile

3. HIV/AIDS Workgroup, Faculty of Medicine, Universidad de Chile, Santiago, Chile

4. FONDAP Center for Genome Regulation, Santiago, Chile

Abstract

Different viruses use different components of cytoplasmic dynein complex to traffic to their replication site. We have found that murine leukemia virus (MLV) depends on dynein light-chain Dynlrb2 for infection, retrograde traffic, and nuclear entry. Our study provides new information regarding the molecular requirements for retrograde transport of MLV preintegration complex and demonstrates the essential role of Dynlrb2 in MLV infection.

Funder

MINEDUC | CONICYT | Fondo Nacional de Desarrollo Científico y Tecnológico

MINEDUC | Comisión Nacional de Investigación Científica y Tecnológica

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00170-21

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