Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Vancomycin in Patients with External Ventricular Drain

Author:

Chen Zhendong1ORCID,Taubert Max1,Chen Chunli12,Dokos Charalambos1,Fuhr Uwe1,Weig Thomas3,Zoller Michael3,Heck Suzette4,Dimitriadis Konstantinos45,Terpolilli Nicole56,Kinast Christina3,Scharf Christina3,Lier Constantin7,Dorn Christoph7,Liebchen Uwe3ORCID

Affiliation:

1. Department I of Pharmacology, Center for Pharmacology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

2. Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, People’s Republic of China

3. Department of Anesthesiology, University Hospital, Ludwig Maximilians University of Munich, Munich, Germany

4. Department of Neurology, University Hospital, Ludwig Maximilian University, Munich, Germany

5. Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig Maximilians University, Munich, Germany

6. Department of Neurosurgery, Munich University Hospital, Munich, Germany

7. Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Regensburg, Germany

Abstract

Vancomycin is a commonly used antibacterial agent in patients with primary central nervous system (CNS) infection. This study aims to examine predictors of vancomycin penetration into cerebrospinal fluid (CSF) in patients with external ventricular drainage and the feasibility of CSF sampling from the distal drainage port for therapeutic drug monitoring.

Funder

China Scholarship Council

China Postdoctoral Science Foundation | Postdoctoral Research Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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