Affiliation:
1. Infectious Disease Service, Brooke Army Medical Center, Fort Sam Houston, Texas
Abstract
ABSTRACT
Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of
Leptospira interrogans
serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference14 articles.
1. Pharmacodynamics of the New Fluoroquinolone Gatifloxacin in Murine Thigh and Lung Infection Models
2. Effects of new quinolones on Mycoplasma pneumoniae-infected hamsters
3. Bal, A. M. 2005. Use of ciprofloxacin for treating leptospirosis—need for clinical trials. J. Med. Microbiol.54:907.
4. Bedos, J. P., E. Azoulay-Dupuis, P. Moine, M. Muffat-Joly, B. Veber, J. J. Pocidalo, and E. Vallee. 1998. Pharmacodynamic activities of ciprofloxacin and sparfloxacin in a murine pneumococcal pneumonia model: relevance for drug efficacy. J. Pharmacol. Exp. Ther.286:29-35.
5. Guidance for industry and reviewers: estimating the safe starting dose in clinical trials for therapeutics in adult healthy volunteers 2002
Cited by
25 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献