Ehrlichia chaffeensis Outer Membrane Protein 1-Specific Human Antibody-Mediated Immunity Is Defined by Intracellular TRIM21-Dependent Innate Immune Activation and Extracellular Neutralization-Reference-Cited by-同舟云学术

Ehrlichia chaffeensis Outer Membrane Protein 1-Specific Human Antibody-Mediated Immunity Is Defined by Intracellular TRIM21-Dependent Innate Immune Activation and Extracellular Neutralization

Published:2019-12 Issue:12 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Velayutham Thangam Sudha¹,Kumar Sandeep¹,Zhang Xiaofeng¹,Kose Nurgun²,Walker David H.¹,Winslow Gary³,Crowe James E.²^ORCID,McBride Jere W.¹⁴⁵⁶⁷^ORCID

Affiliation:

1. Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

2. Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA

3. Department of Microbiology & Immunology, Upstate Medical University, Syracuse, New York, USA

4. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

5. Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas, USA

6. Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA

7. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

Antibodies are essential for immunity against Ehrlichia chaffeensis , and protective mechanisms involve blocking of ehrlichial attachment or complement and Fcγ-receptor-dependent destruction. In this study, we determined that major outer membrane protein 1 (OMP-19) hypervariable region 1 (HVR1)-specific human monoclonal antibodies (huMAbs) are protective through conventional extracellular neutralization and, more significantly, through a novel intracellular TRIM21-mediated mechanism.

Funder

Clayton Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00383-19

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