Antimicrobial Activity of Cefiderocol against the Carbapenemase-Producing Enterobacter cloacae Complex and Characterization of Reduced Susceptibility Associated with Metallo-β-Lactamase VIM-1-Reference-Cited by-同舟云学术

Antimicrobial Activity of Cefiderocol against the Carbapenemase-Producing Enterobacter cloacae Complex and Characterization of Reduced Susceptibility Associated with Metallo-β-Lactamase VIM-1

Published:2023-05-17 Issue:5 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lasarte-Monterrubio Cristina¹^ORCID,Guijarro-Sánchez Paula¹,Vázquez-Ucha Juan Carlos¹^ORCID,Alonso-Garcia Isaac¹,Alvarez-Fraga Laura¹,Outeda Michelle¹,Martinez-Guitian Marta¹²,Peña-Escolano Andrea¹,Maceiras Romina¹,Lence Emilio³,González-Bello Concepción³,Arca-Suárez Jorge¹^ORCID,Bou German¹,Beceiro Alejandro¹^ORCID

Affiliation:

1. Microbiology Department, A Coruña University Hospital Complex (CHUAC), A Coruña Institute for Biomedical Research (INIBIC), CIBER de Enfermedades Infecciosas (CIBERINFEC), A Coruña, Spain

2. NANOBIOFAR, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain

3. Centre for Research in Biological Chemistry and Molecular Materials (CiQUS), Department of Organic Chemistry, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

Abstract

Emergence of cefiderocol resistance among carbapenemase-producing Enterobacterales, particularly those in the Enterobacter cloacae complex (ECC), is becoming of alarming concern; however, the mechanistic basis of this phenomenon remains poorly understood.

Funder

MEC | Instituto de Salud Carlos III

Axencia Galega de Innovación

Ministerio de Ciencia e Innovación

Xunta de Galicia

CIBERINFEC

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01505-22