The 4-Aminomethylphenoxy-Benzoxaborole AN3057 as a Potential Treatment Option for Primary Amoebic Meningoencephalitis-Reference-Cited by-同舟云学术

The 4-Aminomethylphenoxy-Benzoxaborole AN3057 as a Potential Treatment Option for Primary Amoebic Meningoencephalitis

Published:2023-02-16 Issue:2 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ženíšková Kateřina¹,Mach Jan¹^ORCID,Arbon Dominik¹,Štursa Jan²,Werner Lukáš²,Zoltner Martin¹^ORCID,Sutak Robert¹^ORCID

Affiliation:

1. Department of Parasitology, Faculty of Science, Charles University, BIOCEV, Vestec, Czech Republic

2. Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic

Abstract

Primary amoebic meningoencephalitis is a rare but fatal central nervous system (CNS) disease caused by the “brain-eating amoeba” Naegleria fowleri . A major obstacle is the requirement for drugs with the ability to cross the blood-brain barrier, which are used in extremely high doses, cause severe side effects, and are usually ineffective.

Funder

Czech Science Foundation

Charles University Grant Agency

EC | European Regional Development Fund

Czech Academy of Sciences

Gordon and Betty Moore Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01506-22