Absorption, Metabolism, and Excretion of [<sup>14</sup>C]-Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) in Healthy Male Subjects-Reference-Cited by-同舟云学术

Absorption, Metabolism, and Excretion of [¹⁴C]-Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) in Healthy Male Subjects

Published:2023-04-18 Issue:4 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gupta Vipul K.¹^ORCID,Maier Gary²,Gasink Leanne³,Ek Amanda⁴,Fudeman Mary⁵,Srivastava Praveen⁶,Talley Angela¹

Affiliation:

1. Spero Therapeutics, Inc., Cambridge, Massachusetts, USA

2. Maier Metrics and Associates LLC, Worcester, Massachusetts, USA

3. LBG Consulting, LLC, Wayne, Pennsylvania, USA

4. Takeda Pharmaceuticals, Cambridge, Massachusetts, USA

5. ImmunoGen, Inc., Waltham, Massachusetts, USA

6. Nurix Therapeutics, Inc., San Francisco, California, USA

Abstract

Tebipenem pivoxil hydrobromide (TBP-PI-HBr) is an oral prodrug of pharmacologically active moiety tebipenem (TBP), which is a carbapenem with activity against multidrug-resistant Gram-negative pathogens. Conversion from the prodrug to the active moiety, namely, TBP, occurs in the enterocytes of the gastrointestinal tract via intestinal esterases.

Funder

Spero Therapeutics

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01509-22

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