Affiliation:
1. Department of Microbiology, Warner-Lambert Research Institute, Morris Plains, New Jersey 07905
Abstract
A Boivin preparation of
Brucella abortus
, unlike common enterobacterial endotoxins, failed to depress water intake or increase numbers of hemolysin-producing spleen cells in mice, or to cause delayed inflammatory reactions in rabbit skin. Reactivity to the
B. abortus
endotoxin was found only in animals which were previously given the endotoxin with, but not necessarily in, complete Freund's adjuvant. Previous treatment with the endotoxin in saline or with only the adjuvant was ineffective. Sensitization appeared within 10 days and waned after 5 weeks. Passive sensitization was obtained with sensitized donor spleen cells but not with serum. Serum antibody titers did not correlate with the appearance and disappearance of sensitization.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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